a. Inhibited IL-6, TNF-a, and IL-1β in RA-FLS cells.b. Wangbi capsule, whose main effective substances include icariin, reduced PGE2 and IL-1β in adjuvant induced arthritis rat model.c. Inhibited MMP in induction of type II collagen-induced arthritis.d. Reduced MDA levels in LPS-induced synovitis. Here, IL6 is linked to arthritic joint disease.