PLIN1 and malignant glioma: Interestingly, in the bone biopsy from the patient with metastasis of malignant glioma (Figure 3A), we observed an unusual morphology of BMAds characterized by the presence of a large vacuole associated with small lipid droplets that were clustered together beneath the plasma membrane, as better shown by ADIPOQ Figure 3B) and PLIN1 (Figure 3C) immunostaining.