Therefore, in this retrospective study, the severe OHSS rate and clinical pregnancy rate of PCOS patients receiving a fixed GnRH antagonist protocol and a follicular-phase GnRH agonist protocol—based on subgroups classified by AMH and bLH/FSH levels—were evaluated, thereby providing more evidence for the selection of individualized COS protocols for PCOS patients. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.