BGLAP and type 2 diabetes mellitus: Bone turnover markers (BTMs) include osteocalcin (OC), C-terminal telopeptide (CTx) and N-terminal propeptide of type-I procollagen (PINP), and a series of studies have consistently concluded that BTMs were significantly reduced and were associated with increased risks of fragility fracture in patients with T2D compared to healthy controls (5).