In another interesting clinical study in DOR women, there was no statistically improvement in the ovarian reserve markers (AFC, AMH or FSH) after DHEA treatment; however, DHEA supplementation did upregulate the expression of AR and FSHR in GC cells, suggesting an alternative mechanism that non-T androgens such as DHEA may contribute to PCOS pathogenesis (38). This evidence concerns the gene FSHR and polycystic ovary syndrome.