Decreased adiponectin levels in scWAT induced by high prolactin levels and not HFD, may be relevant to obesity and intolerance to glucose evidenced in lacDrd2KO mice, supporting the described role for low adiponectin levels in tissue resistance to insulin, and/or increased adiposity in obese patients, pigs and rodents (57–59). The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.