Interestingly, we found that hyperprolactinemia deepened the alterations in glucose metabolism observed in mice exposed to a HFD, because after 120 minutes, blood glucose levels remained higher compared to genotype- and diet-matched mice at time zero only in the lacDrd2KO-HFD group (Three Way ANOVA, interaction time X genotype X diet F4,72 = 2.94, P=0.026; P time 120 vs. time 0 = 0.98, 0.14, 0.99 and 0.00019 for CD-Drd2 loxP/loxP, HFD-Drd2 loxP/loxP, LacDrd2KO-CD, and HFD-lacDrd2KO mice, respectively (Figure 4). The gene discussed is DRD2; the disease is hyperprolactinemia.