IL1B and hyperprolactinemia: Interestingly, hyperprolactinemia but not fat diet showed a strong tendency to increase the proinflammatory cytokine interleukin-1b Il1b (interaction genotype X diet, F1,18 = 0.78, P=0.39; main effect genotype, P = 0.064, main effect of diet P=0.32, Figure 6G).