GNRH1 and autoimmune thyroid disease: Twelve pathways were significantly enriched in KEGG analysis, including autoimmune thyroid disease, vasopressin- regulated water reabsorption, cortisol synthesis and secretion, GnRH secretion, aldosterone synthesis and secretion, regulation of lipolysis in adipocytes, thyroid hormone synthesis, melanogenesis, ovarian steroidogenesis, GnRH signaling, neuroactive ligand-receptor interaction, and cAMP signaling pathways, etc. Some are related to glucose and lipid metabolism and energy balance (Figure 2B).