found that the abundance of TICs (such as monocytes, resting DCs and M2 macrophages) was associated with poor OS in gastric cancer patients and that the expression levels of most hub TIME-related genes, especially C3AR1, F2R, PLXNC1, CYSLTR1, GHR, GLP2R and RNASE2, were significantly positively correlated with the abundance of TICs (48). This evidence concerns the gene C3AR1 and gastric cancer.