Among the different hemostatic and inflammatory parameters investigated in the present study, by Cox regression univariable analysis, we found that high levels of PAI-1 (HR: 1.043; CI: 95%: 1.007–1.080; p = 0.020), t-PA (HR: 1.091; CI: 95%: 1.016–1.171; p = 0.016), and NLR (HR: 1.089; CI: 95%: 1.032–1.149; p = 0.002) at enrollment were significantly associated with the development of thrombosis during follow-up. The gene discussed is SERPINE1; the disease is Venous thrombosis.