SLC5A2 and type 2 diabetes mellitus: For patients with T2DM and additional CV risk factors who require glucose-lowering therapy despite metformin (and lifestyle modifications), initiation of a sodium-glucose cotransporter 2 (SGLT-2) inhibitor or a glucagon-like peptide 1 receptor agonist (GLP-1RA) may be reasonable to improve glycemic control and reduce CVD risk.