CYCS and Familial prostate cancer: • Punicalagin and ellagic acid induce apoptosis in prostate cancer cells through some basic pathways, such as the introduction of cytochrome c in the cell cytoplasm, upregulation of Bax, and downregulation of Bcl-2 (64). • Urolithin B, a metabolite of ellagitannin, can inhibit testosterone-induced proliferation of MCF-7 cells associated with breast cancer (69). • Pomegranate peel extracts can inhibit the cell proliferation and the expression of angiogenic markers, and activate pro-survival signal pathways (70, 71).