Furthermore, many of the protein targets are components of multiple cell signaling pathways involved in the development of metabolic disorders, such as Peroxisome proliferator-activated receptor gamma (PPARγ), nuclear factor κB (NF-κB)/nuclear factor-erythroid 2 related factor 2 (NRF2), Wnt/β-catenin, NRF2/Kelch-like ECH-associated protein 1 (KEAP1), FOXO, and phosphatidylinositol-3-kinase(PI-3-K)/Akt/tumor necrosis factor-α (TNF-α) (Figure 3) (36). This evidence concerns the gene TNF and metabolic disease.