For instance, Ho et al. (27) proposed that circulating cytokines IL-2 (AUC, 0.78; sensitivity, 86.7%; specificity, 52.9%) and IL-5(AUC, 0.76; sensitivity, 66.7%; specificity, 80.9%) showed great performance in predicting depression in breast cancer. The gene discussed is IL2; the disease is major depressive disorder.