In line with these findings, increased levels of IL-27, found in serum samples and tumor tissues of 4T1+d-MAPPS-treated mice (Figures 2(b) and 2(g)), were accompanied with reduced number of tumor-infiltrated IL-10- and TGF-β-producing, FoxP3-expressing Tregs (Figures 5(e) and 5(f)) and with downregulated serum levels of IL-10 and TGF-β (Figures 2(e) and 2(f)). The gene discussed is TGFB1; the disease is neoplasm.