Analogously, increased concentration of CXCL16, IL-27, IFN-γ, and IL-17 and decreased concentration of TGF-β and IL-10 were measured in the tumors of 4T1+d-MAPPS-treated mice (Figure 2(g); p < 0.001), indicating that modulation of antitumor immune response was mainly responsible for d-MAPPS-dependent suppression of mammary cancer growth. This evidence concerns the gene IL27 and breast cancer.