CXCL16 and neoplasm: Additionally, Th1 cell-derived IFN-γ induces enhanced production of tumorotoxic nitric oxide and TNF-α in tumor-infiltrated macrophages while Th17 cell-sourced IL-17 stimulate production of CXCL16 in tumor DCs, enabling increased recruitment of tumoricidal CCR6-expressing CD8+CTLs [17, 18].