IL27 and breast cancer: Importantly, d-MAPPS significantly increased serum levels of antitumorigenic chemokines and cytokines CXCL16 (Figure 2(a); p < 0.001), IL-27 (Figure 2(b), p < 0.001), IFN-γ (Figure 2(c); p < 0.001), and IL-17 (Figure 2(d); p < 0.001) and downregulated concentration of immunosuppressive cytokines TGF-β (Figure 2(e); p < 0.001) and IL-10 (Figure 2(f); p < 0.001) in mice with established mammary tumors.