IL10 and neoplasm: The tumor microenvironment is characterized by high levels of IL-10 and MDSCs are the principal producers of this cytokine (Cheng et al., 2021) IL-10, in turn, strengthens the immunosuppressive ability of MDSCs in a vicious cycle, by upregulating the expression of different immunosuppressive molecules (Xiu et al., 2015; Lamichhane et al., 2017).