Recently, using different tumor murine models emerged that cDC1 also play a critical role in the induction of the cancer-immune cycle, exercised through the transport of antigens from tumor towards draining lymph nodes, inducing a robust activation/proliferation of CD8+ T cells or transfer of antigen to resident myeloid cells (Roberts et al., 2016; Salmon et al., 2016; Gardner et al., 2020). Here, MPPE1 is linked to neoplasm.