CD4 and juvenile idiopathic arthritis: For instance, the RUNX1 and ETS1 TFs showed elevated binding levels within SE loci of synovial-fluid derived CD4 T lymphocytes in patients with the autoimmune disorder juvenile idiopathic arthritis (JIA), leading to a greater expression of inflammatory genes regulated by these JIA-associated SEs including interleukins and chemokine receptors (Peeters et al., 2015).