IL-1β has also been demonstrated to re-wire the DNA methylome of colon cancer cells by increasing DNMT3a and ablating DNMT3b expression, with minimal changes to DNMT1, leading to reduced CpG island methylation at the promoter regions of the IL-6 and IL-8 proinflammatory cytokine genes (Caradonna et al., 2018). This evidence concerns the gene IL6 and malignant colon neoplasm.