A well-established gene regulatory network that links IL-6-mediated chronic inflammation with cancer consists of two distinct but complementary feedback loops, one involving IL-6, NF-kB, Lin28 and let-7 miRNA, and the other comprising IL-6, NF-kB, STAT3, miR-181b-1, miR-21, CYLD and PTEN (Iliopoulos et al., 2009; Iliopoulos et al., 2010). This evidence concerns the gene STAT3 and cancer.