For example, the application of a commonly utilized NSAID, aspirin, in a mouse model of colitis-linked colon cancer, led to a decrease in the active histone H3K27ac levels and accompanying repression of the proinflammatory genes TNFα, IL-6 and inducible nitric oxide synthase (iNOS) (Guo et al., 2016). Here, NOS2 is linked to colonic neoplasm.