CCL2 and cancer: OIS is widely believed to hinder oncogenesis, owing to its role in restraining cellular proliferation, but it can also promote cancer development through the effect of certain SASP molecules on the cells’ immune system, such as the recruitment of anti-inflammatory M2 macrophages by CCL2 cytokines that sets up an immunosuppressive environment for supporting cancer progression (Allavena et al., 2008), as well as the secretion of proinflammatory SASP factors IL-6 and IL-8 by senescent fibroblasts that stimulates prostate cancer development in mice (Laberge et al., 2015).