In CD4+ T-cells of patients suffering from the autoimmune disease systemic lupus erythematosus (SLE), CBP/p300 is recruited by the STAT family of TF proteins to confer accumulation of another active histone mark, H3K18ac, on the promoter and enhancer domains of the immunomodulatory cytokine gene IL-10, resulting in its upregulation that positively correlates with disease severity (Hedrich et al., 2014). The gene discussed is EP300; the disease is systemic lupus erythematosus.