NF-kB-mediated secretion of IL-6 from immune cells in cancer originating from colon inflammation appears to activate NF-kB and STAT3-dependent signaling in epithelial cells of the gastric mucosa, such as upregulation of DNA methyltransferase activity and associated methylome changes (Hartnett and Egan, 2012). The gene discussed is NFKB1; the disease is colitis.