Prior reports have also provided critical insights into the epigenetic mechanisms that govern the IL-6-induced generation of cancer stem cells (Drost and Agami, 2009; Iliopoulos et al., 2009; Iliopoulos et al., 2010), which are a subset of chemo-resistant tumor cells that drive cancer metastasis (Yu et al., 2012). The gene discussed is IL6; the disease is neoplasm.