A similar function of TGF-β is recapitulated in breast cancer, whereby TGF-β robustly induces a suite of oncogenic EMT TFs like SNAIL, SLUG and TWIST1 to engage the EMT transcriptional program by upregulating mesenchymal cell-specific genes and antagonizing the expression of epithelial cell markers (Dong et al., 2012; Dong et al., 2013). The gene discussed is TGFB1; the disease is breast cancer.