Regulatory kinases may locate directly on the LD surface: the serine/threonine kinase 25 (STK25) is a stress-related kinase which promotes hepatocyte lipid accumulation (Amrutkar et al., 2016); profiling of the STK25-related phosphoproteome co-fractionating with LDs revealed 130 proteins and 60 target phosphosites, enriched for regulators of peroxisomal function and proteostasis responses, providing a mechanistic basis for the involvement of this kinase in non-alcoholic fatty liver disease progression (Nerstedt et al., 2020). The gene discussed is STK25; the disease is metabolic dysfunction-associated steatotic liver disease.