Mutations in VAPB have not been associated with sporadic ALS (Conforti et al., 2006; Kirby et al., 2007) and the frequency of VAPB mutations is low in other populations (Tsai et al., 2011; Ingre et al., 2013; Kenna et al., 2013). Here, VAPB is linked to amyotrophic lateral sclerosis.