VAPB and amyotrophic lateral sclerosis type 8: However, more research is required to clarify in what extend these aggregates form in patients; it has been shown that iPSC-derived motor neurons from ALS8 patients have reduced levels of VAPB and no signs of aggregate accumulation (Mitne-Neto et al., 2011; Oliveira et al., 2020), while ALS8 patient-derived muscle biopsy and fibroblasts revealed VAPB aggregates (Tripathi et al., 2021).