KDM4B and leukemia: At the same time, multiple studies have confirmed that multiple methylases strictly control the cell stemness, senescence (Cakouros and Gronthos, 2020) and differentiation functions (Ye et al., 2012) of MSCs (Sui et al., 2020), and the loss of KDM4B mimics a leukemia-like MSCs(Deng et al., 2021), suggesting that leukemia cells epigenetic change MSCs for its BMM remodeling.