For example, miR-126 secreted by endothelial cells in BM supply quiescence and leukemia growth of BCR-ABL+ LSCs (Zhang et al., 2018) and activated β-catenin in osteoblasts was sufficient to lead to acute myeloid leukemia (Kode et al., 2014). This evidence concerns the gene ABL1 and acute myeloid leukemia.