Furthermore, it has been found that the mitochondrial dihydroorotate dehydrogenase (DHODH) can also inhibit ferroptosis independent of cytoplasmic FSP1 and GPX4 by reducing ubiquinone to ubiquinol and that the DHODH inhibitor brequinar induces ferroptosis and selectively inhibits GPX4low tumor growth (70, 71). Here, DHODH is linked to neoplasm.