Forward stepwise Cox regression analysis (Table 2) identified ALB (>38.95 mmol/L vs. <38.95 mmol/L; hazard ratio [HR], 0.406 [95% CI, 0.191–0.864]; p = 0.019), hsCRP (>2.64 vs. <2.64 mmol/L; HR, 3.721 [95% CI, 1.755–7.887]; p = 0.001), and Hcy (>12.4 vs. <12.4 mmol/L; HR, 5.782 [95% CI, 2.453–13.630]; p < 0.001) as independent risk factors of PFO-related stroke recurrence. This evidence concerns the gene ALB and Patent foramen ovale.