A previous study (Ríos et al., 2012) mentioned cucurbitacin I (also called JSI-124) as a selective inhibitor of phosphorylate tyrosine JAK3/STAT3, and may be considered a potential anticancer agent in addition to cucurbitacins E and B. It has been previously reported (Takahashi et al., 2009) that cucurbitacin D acts as an inducer of apoptosis in hepatic carcinoma. This evidence concerns the gene STAT3 and hepatocellular carcinoma.