This led to the identification of 10 cancer-essential FRGs (ISCU, NFS1, MTOR, EIF2S1, HSPA5, AURKA, RPL8, LONP1, RRM2, and CHMP6) which were closely related to ferroptosis and essential for glioma cell proliferation and survival. The gene discussed is EIF2S1; the disease is central nervous system cancer.