Similarly, high ACLR was also associated with larger tumor size (P < 0.001), higher Edmondson’s grade (P < 0.001), vascular invasion (P < 0.001), higher AFP level (P = 0.038) (Supplementary Figures 3A–D), advanced AJCC stage (P < 0.001), BCLC stage (P < 0.001), and CNLC stage (P < 0.001) (Figures 1D–F). The gene discussed is AFP; the disease is neoplasm.