NNMT and ovarian carcinoma: Moreover, whether it is in glucose-dependent or glucose-independent ovarian cancer cells, ectopic ZEB1 can increase the expression of NNMT and EMT-associated genes, including MMP2, CTGF, and SPARC. In fact, EMT is a result of phenotypic and metabolic plasticity induced by the ZEB1–NNMT axis (80).