In addition, NNMT knockdown upregulated tumor suppressor PP2A activity in GBM by increasing methyl availability for leucine carboxyl methyl transferase 1 (LCMT1) and increasing PP2A methylation while concomitantly decreasing the activity of serine/threonine kinases such as Akt and p38 MAPK (95). The gene discussed is LCMT1; the disease is glioblastoma.