This inducible Dnmt3a KO model has also been combined with a variety of murine models harboring genetic lesions of genes that are commonly co-mutated in human DNMT3A-mutant AML, including FLT3, TET2, IDH2, and KIT, identifying critical cooperative mechanisms that drive leukemogenesis (94, 108, 111, 112). This evidence concerns the gene DNMT3A and acute myeloid leukemia.