NUP98-KDM5A is often associated with acute erythroid or megakaryoblastic leukemia in patients, but when expressed in mouse HSPCs then transplanted into syngeneic recipients leads to an AML-like myeloid phenotype with blasts expressing the mature myleoid markers, Cd11b and Gr1in transplant models (52, 78). This evidence concerns the gene KDM5A and acute myeloid leukemia.