In 2007 Wang et al. (49) showed that retroviral transduction of NUP98-NSD1, the most common NUP98 fusion in pediatric AML, into murine hematopoietic progenitors followed by transplantation independently produced AML with an average survival of 126 days post-transplant (68). This evidence concerns the gene NUP98 and acute myeloid leukemia.