The extrinsic factors of PD-L1 testing and stage at diagnosis vary across the world, the latter of which reflects differences in access; however, the ORIENT-11 study in China used the same staging system [based on American Joint Committee on Cancer (AJCC) as described in the 8th edition of the TNM classification by the International Association for the Study of Lung Cancer) (9, 38) and PD-L1 testing (PDL1 IHC 22C3 pharmDx, Agilent Technologies) (9) as used in the United States. Here, CD274 is linked to lung carcinoma.