Recent studies have shown that β3-AR has a clear implication in the melanoma microenvironment because its expression was found upregulated not only in cancer cells but also in various accessory cells such as stromal, inflammatory, and vascular cells that sustain the tumorigenesis, and through them, the β3-AR causes pro-invasive, pro-angiogenic, and inflammatory effects. The gene discussed is ADRB3; the disease is cancer.