On the other hand, adipose tissues have paracrine functions by secreting adipokines such as adiponectin and leptin or by secreting inflammatory cytokines such as tumor necrosis factor-a (TNF-a), interleukin-6 (IL-6), interleukin-8 (IL-8), plasminogen activator inhibitor 1 (PAI1), etc., which could facilitate cancer growth (4). Here, SERPINE1 is linked to cancer.