The authors suggested that p53 activation is an important process in SIT-mediated apoptosis of non-small cell lung adenocarcinoma (NSCLC) cells, and that SIT elicits ROS-dependent apoptosis in NSCLC cells via downregulating the thioredoxin(Trx)/thioredoxin reductase (TrxR1) signaling pathway. The gene discussed is PRDX5; the disease is non-small cell lung carcinoma.