We further verified the expression levels of ADAMTS9, ENTPD1, FRMD3, PRR15, AKAP12 in THCA, and the results of GEPIA database showed that ENTPD1, FRMD3, PRR15 were obviously increased in tumor tissues (n=512) compared with normal tissues (n=337), and the difference was statistically significant (Figure 3C). This evidence concerns the gene PRR15 and neoplasm.