We used the GEPIA database (http://gepia.cancer-pku.cn/) to investigate the expression levels of CDH2 in THCA tumor tissues (n=512) and matched normal tissues (normal tissues in TCGA + GTEx normal tissues, n=337), and the results showed that CDH2 was significantly higher in tumor tissues than in normal tissues in THCA (Figure 1A). This evidence concerns the gene CDH2 and neoplasm.