However, both corticosteroids and anti-tumor necrosis factor α (TNF-α) drugs have significant side effects, long-term use may have risks of infection, diabetes, osteoporosis, etc. (7) Anti-integrin therapy (vedolizumab) seems safer and has also been reported to be effective in this disease, but it works slowly for severe patients (8, 9).Fecal microbiota transplantation (FMT), a method of putting feces from a healthy donor into the gastrointestinal tract of another patient to restore the balance of gut microbes, is widely used to treat refractory Clostrioides difficile infections (10, 11). The gene discussed is TNF; the disease is diabetes mellitus.