Immune deserts are tumors devoid of immune infiltration, antigen presentation (low major histocompatibility complex-I) and high tumor cells proliferation as seen in tumors such as Head and neck squamous cell carcinomas (HNSCC), glioblastomas, prostate cancer, pediatric malignancies, hormone receptor positive breast cancer (55–57). Here, NR4A1 is linked to head and neck squamous cell carcinoma.