Cancer cells and stromal cells in the tumor immune microenvironment (TIME) are dependent on several factors (nutrients such as glucose, glutamine, fatty acid, molecular oxygen; an acidic environment caused by increased lactate; and monocarboxylate transporter [MCT] proteins, redox control of reactive oxygen species [ROS] generation, and ROS levels in mitochondria) (2–6). Here, SLC16A1 is linked to neoplasm.