HLA-C and hematopoietic and lymphoid cell neoplasm: Recently, the chimeric antigen receptor T (CAR-T) cell therapy has brought a new breakthrough to the treatment of hematological cancers, especially for therapy-resistant and refractory AML patients, with advantages of specific major histocompatibility complex (MHC)-independent antigen recognition, higher proliferation, and manageable cytotoxic capacity (45).