NLRP3 and acute myeloid leukemia: Combined with the above 33 PRGs, a total of 7 pyroptosis-related DEGs were further identified with significant prognostic value for AML patients, of which five genes (CASP1, CASP4, PLCG1, ELANE, and IL1B) were pathogenic genes and two (NLRP2 and NLRP3) had protective roles (Figure 4F).