TNF and acute myeloid leukemia: Principal component analysis (PCA) shows that the healthy control (HC) and AML patients were significantly divided into two groups based on these PRGs (Figure 2B), and the functional enrichment analysis indicated that these PRGs were enriched in immune-related pathways, such as NOD-like receptor signaling pathway, IL-17 signaling pathway, and TNF signaling pathway (Figure 2C).