Based on the Least Absolute Shrinkage and Selection Operator (LASSO) and logistical regression analysis, we ultimately identified 4 key genes to construct the diagnostic model for cluster subtypes in AML, and the nomogram was used to predict the individual clusters, including KIR2DL1, LINC02805, OR52N5, and ERC2 (Supplementary Figures S2H, I). This evidence concerns the gene KIR2DL1 and acute myeloid leukemia.