Combined with the above 33 PRGs, a total of 7 pyroptosis-related DEGs were further identified with significant prognostic value for AML patients, of which five genes (CASP1, CASP4, PLCG1, ELANE, and IL1B) were pathogenic genes and two (NLRP2 and NLRP3) had protective roles (Figure 4F). The gene discussed is ELANE; the disease is acute myeloid leukemia.