It was worth noting that the clustering subtypes reached some consensuses: 1) the pyroptosis-related signatures exhibited complicated expression levels between clusters such as lower levels of CASP1/4 and higher levels of ELANE and NLRP3 in cluster A; 2) Cluster A was a specific phenotype with a better prognosis and slighter clinical FAB phenotypes; 3) Cluster A was identified as an immune-activated subtype with higher TME scores and infiltration degree of adaptive immune response-related immune cells, while cluster B exhibited potential sensitivity to PD-L1 treatment in AML. This evidence concerns the gene CASP1 and acute myeloid leukemia.