Compared with other bone tumor subtypes, the amplification of NCOR1 (P=2.6x10-7), VEGFA (P=1.8x10-7), CCND3 (P=1.7x10-6), GID4 (P=3.6x10-6), MAP2K4 (P=8.5x10-6), CCNE1(P=8.9x10-3), AURKB (P=2.1x10-3), PDGFRA (P=3.0x10-4), KIT (P=5.9x10-4), TSPAN31 (P=0.035), TFFB (P=2.1x10-3), KDR (P=1.7x10-3), ALOX12B (P=0.036), and FUBP1 (P=0.036) were more frequent in osteosarcoma (Figure 3). This evidence concerns the gene MAP2K4 and bone neoplasm.