Similar to the whole bone tumor cohort, the most common mutated genes in osteosarcoma included TP53, NCOR1, VEGFA, CCND3, GID4, RB1, MAP2K4, CCNE1, ATRX, CDK4, CDKN2A, MYC, and PDGFRA (Figure S4). This evidence concerns the gene CCND3 and osteosarcoma.