However, the outcome of IDH-wt astrocytomas is strictly related to several genetic features such as K27M mutation of histone 3 family 3A (H3F3A; H3-K27M); V600E mutation of B-rapidly accelerated fibrosarcoma (BRAF); pTERT-mut; EGFR-amp; and chromosome 7 gain, and chromosome 10 loss (64–67). The gene discussed is IDH2; the disease is astrocytoma (excluding glioblastoma).