Numerous studies have previously described that the role of tumor-infiltrating immune cells in various cancers is increasingly being viewed as a critical factor driving or mediating tumor progression and influencing therapeutic outcomes and patient prognosis (49, 50).Unlike a previous study (42), we further investigate the correlation between PD-L2 and TIICs via GSVA analysis and the online website TIMER. This evidence concerns the gene PDCD1LG2 and neoplasm.