STAT3 and neoplasm: Moreover, tumor-related pathways such as JAK/STAT signaling pathway, Toll-like receptor signaling pathway, PI3K/AKT/mTOR signaling, TGF-beta signaling, IL-2-STAT5 signaling pathway, IL-6-JAK-STAT3 signaling pathway, P53 pathway signaling, TNFA signaling via NFKB were found to be enriched in the high-PD-L2 expression group (Figures 7A-C).