CD274 and breast cancer: As shown in Figure 1A, ethanol exposure significantly accelerated the formation of early onset mammary tumors than that in control group (solid red line vs solid black line, p < 0.05), which was reversed by the injection of PD-L1 or PD-1 antibodies (purple or orange dashed line, respectively, p < 0.05), while PD-L1, PD-1 antibody alone or IgG treatment groups have no significant differences from control group (p > 0.05).