Once activated, platelets release an array of biologically active molecules that can modulate tumor growth, angiogenesis, and metastasis, including transforming growth factor beta (TGF-β1), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF), inducing epithelial mesenchymal transit (12, 13). The gene discussed is VEGFA; the disease is neoplasm.