The lifetime cost of care for an American living with dementia was estimated to be $341,840 in 2017.1 AD is associated with numerous polymorphisms that are often geographic-specific.2,3 One example is the low-density lipoprotein receptor-related protein 1, which is a candidate gene for AD pathogenesis and has a decreasing prevalence from the northern to the southern regions of Europe.3 While significant research is available on risk factors for developing AD, less data are available regarding AD progression and the rate of change among patients with the disease. Here, LRP1 is linked to Alzheimer disease.