CDR2 and major depressive disorder: While much is still being learned about this underrecognized disorder, numerous antibodies have been implicated, including anti-Hu, anti-Ma/Ta, anti-Yo, anti-Tr, anti-Ri, anti-CV2, and anti-GAD.6 Of these, anti-GAD antibodies have been specifically implicated with symptoms of exaggerated startle and rigidity.6 Symptoms vary depending on the patient and the antibody but may include memory loss, dementia, seizures, ataxia, dysarthria, and nystagmus.1 Patients with autoimmune encephalitis may also have psychologic features such as anxiety, depression, mood dysfunction, and hallucinations.7