Functional SOD1 encodes a Cu2+/Zn2+-binding SOD, and converse O2•− to H2O2 and O2 to protect cells from toxic ROS, while in SODG93A mice, a classic ALS model, ROS levels increase due to the SOD1 mutation (Xiao et al., 2018). Here, SOD1 is linked to amyotrophic lateral sclerosis.