Based on these mechanisms, the level and function of proteins and their related-signaling pathways, such as phosphatidylinositol 3-kinase (PI3K/Akt) pathway, NF-KB pathway, and tumor necrosis factor (TNF) pathway, may be dysregulated and thus result in the initiation, progression, and abnormal immune infiltration of cancer [12–15]. This evidence concerns the gene TNF and cancer.