GSEA results reveal that the high-risk group was associated with several cancer progression and metastasis-related pathways, including “cell cycle,” “pancreatic cancer,” “ECM receptor interaction,” “p53 signaling pathway,” “G2M checkpoint,” and “epithelial mesenchymal transition (EMT).” We also investigate the tumor microenvironment difference between two groups. The gene discussed is TP53; the disease is pancreatic neoplasm.