GSEA indicated that GNB4 is involved in various tumor-related pathways, including calcium signalling pathway, cell adhesion molecules cams, regulation of actin cytoskeleton, gap junction, leukocyte transendothelial migration, MAPK pathway, melanoma, pathways in cancer, JAK-STAT pathway, toll-like receptor pathway, ecm receptor interaction, and wnt pathway. This evidence concerns the gene GNB4 and cancer.