In this study, it was found that circ-ABCB10 could target and regulate KLF6, and inhibition of KLF6 could reverse the effects of interfering with cicirc-ABCB10 on the proliferation, apoptosis, migration, and invasion of laryngeal cancer cells, suggesting that cicirc-ABCB10 may affect the progression of laryngeal cancer by regulating KLF6. This evidence concerns the gene ABCB10 and laryngeal carcinoma.