VEGFA and Coats disease: The analysis concluded that patients with Coats disease tend to have a high expression of VEGF in their eyes, and anti-VEGF drug treatment can effectively reduce the level of VEGF in patients' eyes, promote the regression of iris neovascularization, accelerate the absorption of subretinal fluid, and reduce the difficulty of surgery, thus avoiding the adverse outcome of Coats disease patients who eventually have their eyes removed due to the progression of the disease [12].