Compared to normal gastric tissues, 10 core genes, namely, COL1A1, COL1A2, COL3A1, COL5A1, BGN, COL6A3, FN1, COL11A1, COL4A2, and VCAN, were highly expressed in gastric cancer tissues while the expression of GKN1 was significantly decreased. The gene discussed is FN1; the disease is gastric cancer.