In PC, a Phase 1b trial investigated the efficacy of pegylated interleukin 10 combined with FOLFOX chemotherapy in the second-line setting and reported a median OS of 10.2 months that is superior to historical controls.[14] An ORR of 10% and a 6-month disease control rate of 13% were demonstrated in another Phase Ib trial that evaluated the combination of the anti-colony-stimulating factor (CSF) CSF1 receptor antibody cabiralizumab with nivolumab in 31 advanced PC patients who had prior chemotherapy.[15] Three confirmed PRs were in patients with MSS tumors. The gene discussed is CSF2; the disease is pachyonychia congenita.